Understanding Granulation in Pharmaceutical Production
April 11, 2024

Understanding Granulation in Pharmaceutical Production

Granulation serves as the backbone for the production of solid dosage forms. In this article, we'll delve into the intricacies of granulation: what it entails, its significance, and the various methodologies employed. Additionally, we'll explore how Schematic's products play a vital role in optimising granulation processes for pharmaceutical manufacturing.

What is Granulation?

Granulation is a process integral to the production of solid pharmaceutical dosage forms, wherein small particles are agglomerated to form granules. These granules serve as the foundation for various forms such as tablets, capsules, and granules themselves.

The Reason for Granulation

Granulation serves several crucial purposes in pharmaceutical manufacturing:

  1. Improved Flowability and Uniformity: By converting fine powders into granules, the flow properties of the material are enhanced, ensuring consistent and uniform dosage in each unit.
  2. Enhanced Dispersion and Dissolution: Granules exhibit superior dispersibility and dissolution rates compared to powders, facilitating optimal drug absorption in the body.
  3. Reduced Dustiness: Granules mitigate the risk of airborne particles, offering a safer working environment and minimising product loss.

Types of Granulation

Granulation techniques can be broadly categorised into three main types:

  1. Wet Granulation: This method involves the addition of a liquid binder to the powder mixture, followed by agitation to form granules. It is particularly suitable for moisture-sensitive compounds and those requiring rapid drying.
  2. Dry Granulation: In contrast to wet granulation, dry granulation does not involve the use of liquid binders. Instead, the powder mixture is compacted and then broken down into granules. This approach is ideal for moisture-sensitive or chemically unstable compounds.
  3. Direct Compression: While not a granulation method per se, direct compression involves compressing the powdered blend directly into tablets without the need for granulation. However, it may not be suitable for all formulations and may require additional processing steps for certain drug substances.

How We Can Help

At Schematic Engineering Industries, we specialise in providing cutting-edge solutions for granulation processes. Our Granulation Line Isolators offer a comprehensive range of equipment tailored to meet the diverse needs of pharmaceutical manufacturers:

  • Granulators: Versatile processors suitable for various granulation techniques, including wet and dry granulation.
  • Fluid Bed Dryers: Essential for drying granules in wet granulation processes, ensuring optimal moisture content.
  • Dry and Wet Mills: Precise milling equipment for achieving the desired particle size distribution.
  • Blenders: For homogenizing granule blends, ensuring uniform composition.

Our Granulation Isolators are designed to meet stringent containment requirements, safeguarding both product integrity and operator safety. From Research and Development labs to full-scale production facilities, we offer scalable solutions to suit every need.

Our Products: Granulation Line Isolators

Our Granulation Line Isolators cater to a wide range of production capacities:

  • 200g - 2kg: Ideal for R&D labs and small-scale production.
  • 600g - 5kg
  • 2kg - 10kg: Suitable for larger production volumes.

Whether it's wet granulation or dry granulation, we have the expertise and experience to deliver tailored solutions that meet the highest standards of quality and efficiency.

Explore our product here.


Granulation stands as a cornerstone process in pharmaceutical manufacturing, enabling the production of high-quality solid dosage forms. With our state-of-the-art Granulation Line Isolators and comprehensive range of equipment, Schematic Engineering Industries is committed to empowering pharmaceutical manufacturers with the tools they need to succeed in today's dynamic market landscape. Reach out to us today to learn more about how we can elevate your granulation processes to new heights.

Contact us here.

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