Granulation Line Isolators

Granulation Line Isolators
Granulation Line Isolators
Granulation Line Isolators
Granulation Line Isolators
Granulation Line Isolators
Granulation Line Isolators
Granulation Line Isolators
Granulation Line Isolators

Granulation Line Isolators

Schematic Engineering Industries manufacture a wide range of Granulation Isolators which includes;

  • Granulators
  • Fluid Bed Dryers
  • Dry and Wet Mill
  • Blenders

Granulation isolators typically are offered in;

  • 200g - 2kg (Typically used in Research and Development labs)
  • 600g - 5kg
  • 2kg - 10kg

There are two types of Granulation Lines employed in the production of solid dosage forms in the Pharmaceutical Industry;

  • Wet Granulation
  • Dry Granulation

In essence, a granulator is a multipurpose processor that is suitable for the high-speed dispersion of dry powders, aqueous or solvent granulations and effervescent products as well as wet and melt palletisation.

Schematic Engineering has developed and supplied Barrier Isolator equipment solutions for both Dry Granulation and Wet Granulation and has a vast amount of experience servicing both types of Granulation production Lines.

Wet Granulation Line

Schematic provides machines, equipment and barrier isolators for the wet granulation line including the Feed Station, Milling, Sieving, High Shear Mixing, Fluid Bed Processing and Blending. Schematic has also fully integrated barrier isolator solutions for the Tablet Press Machine and Coating Machine and can supply turnkey solutions for Vacuum powder transfer systems powder and CIP / WIP systems.

The process of wet granulation involves the addition of a liquid solution to a powder mixture and the massing of the mix to produce granules. Typical liquids include water, ethanol and isopropanol and once the powders have formed into a dense mass and the granulation fluid has been evaporated then the granules are milled to an appropriate size for compression.

The exact process depends on the characteristics of the powders and the final dosage form. Organic solvents are used when water sensitive drugs are processed, as an alternative to dry granulation, or when a rapid drying time is required.

As direct compression is not the best technology for many active substances, wet granulation is still a preferred method. Even if the active substance is sensitive to hydrolysis, modern equipment such as a fluidized bed eliminates the problems associated with wet granulation. Products including anti-neoplastic agents/Hormones(OEB3) may be produced using wet granulation. Below shows an example of a 2kg Granulation Line Barrier Isolator including Rapid Mix Granulator (RMG), a Fluid Bed Dryer (FBD) and Multi-mill blender workstations, designed and manufactured by Schematic.

Dry Granulation Line

The Dry Granulation process is used to form granules without using a liquid solution. This process is typically employed if the mixture to be granulated is sensitive to moisture, physically or chemically unstable when exposed to moisture and heat. Forming granules without moisture involves compacting and size reduction of the mix to produce a granular, free flowing blend of uniform size.

Dry granulation can be done in two ways, either;

  • a large tablet (slug) is produced in a heavy duty tableting press or
  • the powder is squeezed between two rollers to produce a sheet of materials (roller compactor/chilsonator).

When a tablet press is used for dry granulation, the powders may not possess enough natural flow to feed the product uniformly into the die cavity, resulting in varying degrees of densification.

The roller compactor (granulator-compactor) uses an auger-feed system that will consistently deliver powder uniformly between two pressure rollers. When the product is compacted properly, it can then be passed through a mill and final blend before tablet compression.

By way of example, for such Dry Granulation applications Schematic has supplied Barrier Isolators with Dry milling, weighing and dispensing, Hoister, Hammer Mill and Sieving workstations.

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Design Features

  • ISO5 to ISO8 class design
  • OEB4 and OEB5 levels
  • Capacity from 2-20 Kg/hr
  • RTP / polycoater can be used for material charging and discharge
  • PLC for operating and monitoring
  • Negative and positive pressurised chambers
  • Auto pressure test (ISO 10648-2)
  • Pass box and intermediate door pneumatic interlocks
  • Main chamber glass door is electro and pneumatic interlocks

Technical Specification

  • 316 S/S internal construction with 304 Stainless Steel external cladding
  • Exhaust blow air with multi positional valve
  • Filtration through Double HEPA (safe change)
  • Elliptical glove ports with Hypalon Gloves
  • Drain Tank
  • PTFE wash gun for cleaning
  • Interlocking between pass box and intermediate door
  • Magnetic gauges for pressure monitoring
  • Tower lamp for Isolator health and contamination breach
  • FBD, RMG, Dry Mill, Wet Mill, Multi-Mill and Blender as standard workstations
  • Leakproof toughen Glass door

Operational Benefit


  • Formulation Lines
  • Food Industries
  • Chemical Industries

Supply Options

  • Full Glove material options: EPDM, Butyle and PU Gloves
  • Split Glove Design options

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