Understanding ANFD and Its Role in Chemical and Pharmaceutical Industries
May 27, 2024

Understanding ANFD and Its Role in Chemical and Pharmaceutical Industries

What is an Agitated Nutsche Filter Dryer (ANFD)?

An ANFD is a multifunctional system used for filtration, washing, and drying of various substances, particularly those in powder and liquid forms. The system's versatility and efficiency make it indispensable in processing industries where purity and precision are paramount.

ANFD in Chemical Plants

In chemical plants, ANFDs play a vital role in the separation and purification processes. These units are designed to handle the rigorous demands of filtering and drying high-value, sensitive materials. The primary uses of ANFDs in chemical plants include:

  • Filtration: Separating solid particles from liquids with precision, ensuring the clarity and purity of the final product.
  • Washing: Efficiently washing the filtered solids to remove impurities and residual solvents.
  • Drying: Drying the filtered and washed solids under vacuum to achieve the desired moisture content without compromising the integrity of the product.

ANFD in the Pharmaceutical Industry

The pharmaceutical industry requires stringent control over every step of the production process to ensure the safety and efficacy of medications. ANFDs are integral to this process due to their ability to:

  • Maintain High Purity: By preventing cross-contamination and ensuring that all particles are effectively filtered and dried.
  • Handle Sensitive Materials: Managing highly potent compounds and active pharmaceutical ingredients (APIs) with care, reducing the risk of exposure to operators and the environment.
  • Comply with Regulations: Meeting the strict guidelines of cGMP (current Good Manufacturing Practices) and cGAMP (current Good Automated Manufacturing Practice).

How Does an Agitated Filter Dryer Work?

An agitated filter dryer operates through a series of well-coordinated steps:

  1. Loading: The slurry containing the solid-liquid mixture is loaded into the filter dryer.
  2. Filtration: The mixture is subjected to pressure or vacuum filtration, separating the solid cake from the liquid filtrate.
  3. Washing: The solid cake is washed to remove impurities. This step can be repeated as necessary.
  4. Drying: The washed solid cake is then dried under vacuum. The agitator ensures uniform drying by continuously mixing the solids.
  5. Discharge: Once the drying process is complete, the dried solids are discharged.

Our Product: ANFD Discharge Isolators

At Schematic, we specialise in manufacturing and installing bespoke, client-specific barrier isolator systems for ANFDs. Our ANFD Discharge Isolators are designed to meet the highest standards of cGMP and cGAMP.

Key Features of Our ANFD Discharge Isolators:

  • Rigid Barrier Isolator Systems: Ensuring a controlled environment with either a negative or positive pressurised internal environment, depending on the processed media.
  • Negative Pressure Isolators: Essential for handling hazardous or highly toxic materials. This setup ensures that any potent vapors are safely filtered and exhausted away from the operator, providing a risk-free working environment.
  • Positive Pressure Isolators: Used when it is critical to prevent external contaminants from entering the processed batch, maintaining the purity of the product.
  • Advanced Mixing Agitators: Our ANFD designs feature a differential mixing agitator and paddle that moves vertically to ensure thorough mixing. The agitator consists of sharp curved blades that penetrate difficult cakes without stressing the product.
  • Material Versatility: Our systems can be constructed from a range of materials, including Hastelloy, to suit specific process requirements.

Contact Us

Schematic, as part of the Standard Group of Companies, is dedicated to delivering high-quality, custom-engineered process equipment. Our expertise in reactors and ANFDs, combined with our advanced barrier isolator systems, ensures that we can meet the unique needs of your operation.

For more information on our ANFD Discharge Isolators and to learn about the operational benefits of our turnkey solutions, click here.

Contact us today to discuss your specific requirements and how we can help optimise your processing operations.

Why Partner With Us?

Logistics, API, Formulation & Injectable Equipment Solutions
Schematic and the wider Standard Group offer 95% of ALL products required for Pharmaceutical processing.